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胃肠道间质瘤的临床病理分析 被引量:2

Gastrointestinal Stromal Tumor Clinical Performance and Diagnosis
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摘要 目的:探讨胃肠道间质瘤(GIST)的临床表现、病理学和免疫组化特点及诊断、治疗方法。方法:对57例GISTs患者的临床资料和病理资料进行回顾性分析。结果:GIST主要发生在胃和小肠,结肠、直肠和肠系膜较少;内窥镜检查阳性率89%,消化道造影阳性率77%,CT阳性率为97%;免疫组织化学染色显示CD117、CD34表达的阳性率分别是84.2%、73.2%。结论:GIST是一种具有潜在恶性的肿瘤,其确诊有赖于病理组织学和免疫组化检查,CD34和CD117阳性在诊断上有其特殊意义;手术仍是主要治疗手段。 Objective :To explore the clinical behavior, Pathological and immunohistochemical characteristics and diagnosis, and treatment methods of gastrointestinal stromal tumors (GIST). Methods:Retrospective analysis was perfomed over 57 GISTs patients based on clinical data and pathological data. Results : GIST occurred more in the stomach and small intestine, than colon, rectum and mesenteric. Endoscopy positive rate was 89 %, gastrointestinal imaging positive rate was 77%, CT - positive rate was 97 %. Immunohistochemical staining showed CD117, CD34 expression, the positive rates were 84.2%, 73.2%. Conclusion : GIST is a potentially malignant tumor. GIST diagnosis depends on the histologic and immunohistochemical test. CD34 and CD117 in the positive diagnosis has its special significance. Surgery is the main treatment.
作者 尚瑞刚 闫军
机构地区 山西医科大学
出处 《长治医学院学报》 2008年第2期98-100,共3页 Journal of Changzhi Medical College
关键词 胃肠道间质瘤 诊断 外科治疗 GIST Diagnosis Surgical treatment
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  • 1[1]Mazur MT, Clark HB. Gastric stromal tumors: reappraisal of histogenesis. Am J Surg Pathol,1983;7: 507~19
  • 2[2]Kindblom LG, Remotti HE, Aldenborg F et al. Gastrointestinal pacemaker cell tumor (GIPACT) : gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol, 1998;152:1259~69
  • 3[3]Franquemont DW. Differentiation and risk assessment of gastrointestinal stromal tumors. Am J Clin Pathol, 1995;103:41~7
  • 4[4]Sarlomo-Rikala M, Kovatich A, Barusevicius A et al. CD117: a sensitive marker for gastrointestinal stromal tumors that is more specific than CD34. Mod Pathol, 1998; 11: 728~34
  • 5[5]Sircar K, Hewlett BR, Huizinga JD et al. Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors. Am J Surg Pathol, 1999; 23: 377~89
  • 6[6]Lecoin L, Gabella G, Le Douarin N. Origin of the c-kit positive interstitial cells in the avian bowel. Development, 1996;122: 725~33
  • 7[7]Young HM, Ciampoli D, Southwell BR et al. Origin of interstitial cells of Cajal in the mouse intestine. Dev Biol, 1996;180: 97~107
  • 8[8]Hirota S, Isozaki K, Moriyama Y et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science, 1998; 279: 577~80
  • 9[9]Matsuda R, Takahashi T, Nakamura S et al. Expression of the c-kit protein in human solid tumors and in corresponding fetal and adult normal tissues. Am J Pathol, 1993; 142: 339~46
  • 10[10]Arber DA, Tamayo R, Weiss LM. Paraffin section detection of the c-kit gene product (CD117) in human tissues: value in the diagnosis of mast cell disorders. Hum Pathol, 1998; 29: 498~504

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