氨溴索对头孢哌酮肺转运作用的临床研究

Clinical study of ambroxol's effect on cefoperazone's transport into pulmonary

目的了解氨溴索(ambroxo1)对头孢哌酮(cefoperazone)的肺转运作用。方法选择呼吸道疾病住院病人30例,随机分为2组对照组12例,实验组18例,每例病人在检查前均头孢派酮(施乐欣)2.0加入NS200ml中静脉滴注每日两次,滴速每分钟5ml,实验组在头孢派酮滴注100ml时从静滴针头处直接加盐酸氨溴注射剂30mg+NS20ml静脉推注时间不少于5min,每日2次,3d后收集及测量支气管肺泡灌洗液(BAIF)中头孢哌酮(cefoperazone)的浓度及血清中的头孢哌酮(cefopera-zone)的浓度。结果实验组BAIF中头孢哌酮的含量(4.11±0.32)较对照组(3.12±0.53)高(P<0.05),两组的头孢哌酮血浆浓度无显著差异性(P>0.05)。结论氨溴索有促进头孢哌酮肺内转运的作用。

Objective To comprehend the anmbroxol＇s effect on the transport of cefoporazone into pulmonary. Method 30 patients with respiratory diseases were randomly assigned into two groups, 12 in control and 18 in experimental group. All patients received intravenous drip of cefoperasone 2.0 dissolve in 200ml normal saline at the speed of 5 ml/min, twice a day. While dripping half, 30 mg ambroxol dissolve was added in 20ml normal saline intravenous injection with no less than 5 minutes. The control group received the same treatment except using ambroxl. Bronchoalveolar lavage fluid （BALF） and plasma were collected in 3 days after treatment and cefoperazone concentration was measured. Results Cefoperasone concentration in BALF in the experimental group （4. 11 ±0. 32） mg/L was significantly higher than that in the control （3.12 ± 0.53 ）rag/L（ P 〈 0.05 ）. There was no significant difference in plasma cefoperazone concentration between the two groups. Conclusion Ambroxol facilitates cefoperazone transport into pulmonary.