67例膀胱浅表性肿瘤术后化疗分析

The review of 67 cases of superfical bladder cancer after operation treated by infusion chemotheraphy

目的观察膀胱癌术后灌注化疗防治膀胱癌术后复发的疗效。方法A组患者用丝裂霉素C40mg溶于无菌生理盐水40ml，膀胱内灌注，每周1次，共6次，再序联用BCG 150mg加IL-21．0×10^5 U溶于无菌生理盐水40ml，膀胱内灌注，每周1次，共6次，此后用BCG 150mg加IL-21．0×10^5U溶于无菌生理盐水40ml，膀胱内灌注，每月1次，共2年。B组患者用丝裂霉素C40mg溶于无菌牛理盐水40ml，膀胱内灌注，每周1次，共6次，改为每月灌注1次，共2年。结果随访24～30个月，A组平均27个月，有效率93．3％B组平均28个月，有效率43．2％。结论MMC序联BCG加IL-2膀胱内灌注较单用MMC更有效地防治膀胱癌术后复发。

Objective To observe the effects of infusion chemotherapy for preventing bladder cancer recurrence after operation. Methods 67 cases were divided into two groups. The patients in group A used MMC 40mg dissolved in sterile saline 40ml that were infused in bladder once a week, after six times, combined with BCG 150mg plus IL - 2 1.0 × 105u. All these medicines were dissolved in sterile saline 40ml that were irrigated in the bladder once a month, for a total of two years. The patients in group B with MMC 40mg dissolved in sterile saline 40ml that were infused once a week, a total of six weeks, the re - in- fusion once a month, for a total of two years. Results 24 - 30 months in follow up, an average of 27 months in group A, the ef- fective rate is 93.3% , the group B effective rate is 43.3% , on average 28 months. Conclusion MMC combine with BCG and IL -2 infused in bladder were much more effective than MMC alone to prevent bladder cancer recurrence.