反相微乳液法制备糊精纳米微球

Preparation of dextrin nanosphere with inverse microemulsion

以正己烷为油相,去离子水为水相,Span 60和Tween 60为表面活性剂,正戊醇为助表面活性剂配制微乳液,对影响微乳液特性的各因素做了分析。并以糊精为原料,三偏磷酸钠为交联剂,制备糊精纳米微球。结果表明,在微乳液体系中,表面活性剂的量与体系溶水能力在一定范围内正向相关,而助表面活性剂正戊醇对溶水能力则具有逆向作用。红外光谱测试证实糊精与三偏磷酸钠发生交联,经扫描电镜观察,糊精微粒纳米形态均一,粒径在500～600 nm之间。

An inverse microemulsion was prepared with distilled water as water phase, n-hexane as organic phase, and Span 60 mixed with Tween 60 as emulsifying agent and n-pentanol as co-emulsifying agent. The dextrin nanosphere was then prepared with the inverse microemulsion by using Na3P3O9 as cross-linking agent and dextrin as raw material. The results showed that the emulsifying agent was in positive correlation to water solubility, whereas n-pentanol co-emulsifying agent was in negative correlation to water solubility in the system of inverse microemulsion. The cross linking reaction taking place successfully was confirmed by infra-red spectrum analysis. A uniform dextrin nanosphere with a diameter of 500-600 nm was measured with scanning electronic microscope.