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温心汤对慢性心力衰竭患者血清脑钠肽水平的影响及疗效分析 被引量:10

Clinical effect of Wen Xin Tang on the disease of chronic heart failure and the impact of B-type natriuretic peptide (BNP)
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摘要 目的:观察温心汤对慢性心力衰竭患者血清脑钠肽(BNP)水平的影响及其治疗效果。方法:70例慢性心力衰竭患者随机分为常规西医治疗组和常规西医+温心汤治疗组2组,每组35例,2周后观察2组治疗前、后的中医证候积分疗效及临床心功能分级情况,并检测治疗前、后的血清BNP的水平。结果:治疗2周后,常规西医治疗组和常规西医+温心汤治疗组心功能改善的总有效率分别为83.0%,88.0%,差异无统计学意义(P>0.05),中医证候疗效总有效率分别为83.0%,88.0%,差异有统计学意义(P<0.05)。2组治疗前、后血清BNP水平比较其差异有统计学意义(P<0.05)。结论:温心汤对慢性心力衰竭患者有疗效。温心汤可能通过神经内分泌调节,降低慢性心力衰竭患者体内血清BNP的水平,从而改善患者的心功能。 Objective: To observe the clinical effect of Wen Xin Tang (WXT) on the disease of chronic heart failure and through clinical research probing the impact of WXT on BNP in patients with chronic heart failure. Methods: Seventy patients with chronic heart failure were divided randomly into two groups, each group was 35. Two groups were treated with western medicine, while the WXT group was treated with WXT as well as western medicine. Two weeks later, we observed the effect on the patients. Observing the symptoms signs and NYHA-class before and after the treatment, BNP in the blood was measured before and after the treatment. Results: After two weeks of treatment , the effective rate was 82.86% in the western medicine group and 88.57% in the WXT group; The difference was not ignificant (P〉0.05). Alleriating symptoms of Traditional Chinese Medicine of effective rate was 82. 86% in the western medicine group and 88.57% in the WXT group; Alleriating symptoms of Traditional Chinese Medicine were signifi- cant between the two groups (P 〈0.05). NYHA-class of the western medicine group was the same as the WXT group. Alleriating symptoms of Traditional Chinese Medicine of the WXT group was better than the western medicine group. The difference was significant (P 〈0.05). After treatment the level of BNP reduced in the two groups. The level of BNP in the WXT group was lower than in the western medicine group, The efffct of level of BNP in the WXT group was better than the western medicine group. Conclusions: Wen Xin Tang has a constant effect on the chronic heart failure patients. The mechanism of action of WXT could be that it put down the contents of BNP in the blood-serum by regulating neurohormonal function and in this way it could protect the cardiac function.
出处 《新疆医科大学学报》 CAS 2008年第5期564-566,共3页 Journal of Xinjiang Medical University
关键词 温心汤 慢性心力衰竭 血清脑钠肽 中医治疗 Wen Xin Tang chronic heart failure B-type natriuretic peptide (BNP) treatment of Tradi- tional Chinese Medicine
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