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耐甲氧西林葡萄球菌对常用抗菌药物的敏感性研究 被引量:3

Antimicrobial Susceptibility Study of MethicillinResistant Staphylococcus Aureus and Staphylococcus Epidermidis to Common Antimicrobial Agents
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摘要 本研究采用琼脂平皿双倍稀释法测定了本院19964~19973月临床分离的耐甲氧西林金葡菌和表葡菌(MRSA和MRSE)对七种常用抗菌药物的敏感性。在所试药物中,氧氟沙星对MRSA和MRSE的体外抗菌活性最好:MIC50(MIC90)为4(64)和4(16)μg/ml;其次是利福平,MIC50(MIC90)为2(256)和4(16)μg/ml。庆大霉素、红霉素、磷霉素和磺胺类对MRSA和MRSE的体外抗菌活性较差,MIC50高于64μg/ml。MRSA和MRSE对红霉素的耐药率最高(8406%和9200%),其次是TMPSMZ(8841%和8400%)、TMP(8400%和8116%),磷霉素(8261%和7600%)。MRSA对氧氟沙星的耐药率(4348%)略高于利福平(2609%),MRSE对氧氟沙星的耐药率(3600%)略低于利福平(5200%)。由上可知,MRSA和MRSE耐药现象严重,同时耐多种抗生素的菌株广泛存在,临床上如遇MRSA和MRSE引起的感染,要避免选用红霉素、TMPSMZ、TMP、磷霉素这几类药物,应依照药敏试验结果选药或选择目前较敏感的糖肽类、氟喹诺酮? The study was performed to determine the susceptibility of oxacillinresistant Staphylococcus aureus and Staphylococcus epidermidis(MRSA and MRSE)clinical isolates in our hospital to seven general antimicrobial agents by serial twofold agar dillution method.The results stated that ofloxacin produced the best invitro activity against MRSA and MRSE among the seven antibiotics,the MIC50(MIC90) are 4(64)and 4(16)μg/ml,The next one is rifampin,MIC50(MIC90) are 2(256) and 4(16) μg/ml respectively.The MIC50 of gentamycin against MRSA and MRSE are 128 and 32 μg/ml separately.The MIC50 of erythromycin phosphomycin,TMP and TMPSMZ are higher than 64 μg/ml.The resistant rate of MRSA and MRSE to erythromycin is the highest(8406% and 9200%),subsequently is TMPSMZ(8841% and 8400%),TMP(8400% and 8116%),phosphomycin(8261% and 7600%),gentamycin(7826% and 4400%).The resistant rate of MRSA to ofloxacin(4348%)is mildly higher than that of rifampin(2609%),and the resistant rate of MRSE to ofloxacin(3600%) is lightly lower than that of rifampin(5200%).From these results,severe resistance to multiple antimicrobial agents and higher resistant rate existed in MRSA and MRSE.If the infection is caused by MRSA and MRSE,these varieties of antibiotics should be avoided of beign choiced,the glycopeptides,fluroquinolones and new microlides possisoned high antimicrobial activities to MRSA and MRSE,they are suggested to be used in these infections.
出处 《华西医学》 CAS 1997年第4期409-411,共3页 West China Medical Journal
关键词 葡萄球菌 抗生素 药敏试验 MRSA MRSE Staphylococcus aureus Staphylococcus epidermidis Antimicrobial susceptibility
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