国产尿激酶溶栓治疗急性心肌梗死60例临床研究

Clinical Study of Intravenous Thrombolysis Using China-made Urokinase in AMI Patients of 60 Cases

目的研究国产尿激酶静脉溶栓治疗急性心肌梗死的临床疗效。方法120例AMI患者随机分为溶栓组和未溶栓组,溶栓应用国尿激酶静脉溶栓治疗,未溶栓组应用除溶栓外的常规内科治疗。观察两组治疗效果,同时观察不同溶栓时间的治疗效果。结果溶栓组再通率为68.3%,病死率及发生心衰,心源性休克,严重心律失常显著低于未溶栓组,出血发生两组无显著差异。6小时溶栓效果优于6-12小时溶栓。结论国产尿激酶静脉溶栓治疗AMI效果好,值得基层医院推广应用。

Objective To study the clinical efficacy of applying home made urokinase to treat acute myocardial infarction patients with intravenous thrombolytic therapy. Methods 120 AMI patients were randomly divided into thrombolysis group and non thrombolysis group. Thrombolysis group was applying intravenous thrombolysis using china-made urokinase, while non-thrombolysis group was given conventional medical treatment, and then observed the efficacy of two groups and efficacy of treatment of thrombolysis in different time. Results The recanalization rate of thrombolysis group was 68.3%, the mortality rate and the incidence of congestive heart failure, cardiac shock, and severe arrhythmia was obviously lower than that of non thrombolysis group. There had no significant difference in hemorrhage symptom. And the 6h thrombolysis was superior to 6-12h thrombolysis. Conclusions Apply home made urokinase to treat acute myocardial infarction patients with intravenous thrombolytic therapy has good effect, which is worth of spreading in primary hospitals.