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Shh基因在胚胎发育过程中的调控作用 被引量：7

Function of Shh gene in the development of embryos
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摘要 Mammals have three genes with homology to the hh gene.These comprise Sonic hedgehog(Shh),Indian hedgehog(Ihh),and Desert hedgehog(Dhh).Shh has been shown to play a crucial role in embryogenesis and the development of ectoderm.Shh has the great relationship with the forming all the system.Shh-Patched-Smoothened signal pathway will lead the embryogenesis in the normal way.Otherwise,the abnormal embryogenesis,malformation,and tumor will be happened. Mammals have three genes with homology to the hh gene. These comprise Sonic hedgehog （Shh） , Indian hedgehog （lhh） , and Desert hedgehog （Dhh）. Shh has been shown to play a crucial role in embryogenesis and the development of ectoderm. Shh has the great relationship with the forming all the system. Shh-Patched-Smoothened signal pathway will lead the embryogenesis in the normal way. Otherwise, the abnormal embryogenesis, malformation, and tumor will be happened.
作者 周昱男 胡波
机构地区 华中科技大学同济医学院附属协和医院神经内科
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2008年第6期1240-1243,共4页 Chinese Journal of Pathophysiology
基金 国家自然科学基金资助项目(No30600189)
关键词 基因 SHH 转录因子Gli 胎儿发育 Genes, Shh Transcription factor Gli Fetal development
分类号 R363 [医药卫生—病理学]
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参考文献30

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共引文献96

同被引文献99

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中国病理生理杂志
2008年 第6期

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