尿微量蛋白检测对Ⅱ型糖尿病早期肾病的诊断意义

DIAGNOSTIC SIGNIFICANCE OF SMALL PROTEIN DETECTION IN URINE TO EARLIER DIAGNOSIS OF DIABETIC NEPHROPATHY OF NON-INSULIN DEPENDENT DIABETES

[目的]探讨Ⅱ型糖尿病(NIDD)患者尿微量蛋白的检测对糖尿病早期肾损伤的诊断意义及病情进展中的应用价值。[方法]应用放射免疫比浊法测定确诊糖尿病患者的尿中各种微量蛋白的含量,并与健康体检者相对照。[结果]糖尿病组尿微量蛋白测定结果均明显高于健康对照组,差异有统计学意义(P﹤0.01)。糖尿病组中,尿mAlb、IgG、β2-MG、TRF、α1-MG阳性率分别为52.3%、73.8%、44.6%、58.5%、15.4%,5个检测指标至少一个高于正常对照组为阳性,阳性率为87.5%。[结论]尿微量蛋白检测有助于提高糖尿病早期肾病的检出率,确切判断其病变部位及损伤程度,对早期诊治糖尿病肾病有重要的临床意义。

[Objective] To approach the detection of small protein detection in the urine of NIDD patients, and to cartier diagnosis of diabetic nephmpathy and study its value itl the progress of nephropathy. [Methods] Various small proteins hi urine of diabetic were detected with radio-immunoturbidimetry and compared with those of healthy physical examinees. [ Results] Small proteins in urine of diabetics were significantly higher than those of healthy physical exanfinees （P 〈 0.01 ）. Among the diabetics group, the positive rates of mAlb, lgG, β2-MG, TRF, and α1-MG in diabetics＇ urine were 52.3%, 73.8%, 44.6%, 58.5% and 15.4%, respectively. Among five detective indexes, one index which was significandy higher than that in control group diagnosed to be positive, which positive rate was 87.5%. [Conclusion] The detection of small proteins in urine is helpfid to elevate the detection rate of diabetic nephropathy and certainly judge diseased region and degree of injury precisely, which is important to early diagnose and cure diabetic nephropathy.