AMI患者治疗前后血浆Hcy和ET检测的临床意义

Clinical Significance of Measurement of Changes of Plasma Hcy and ET Levels After Treatment in Patients with Acute Myocardial Infarction(AMI)

目的:探讨了急性心肌梗死(AMI)患者治疗前后血浆Hcy和ET水平的变化。方法:应用放免法测定了33例AMI患者的血浆Hcy和ET含量,并与30名正常健康人作比较。结果:AMI患者在治疗前后血浆Hcy和ET水平非常显著地高于正常人组(P<0.01),并且呈显著的正相关(r=0.5988,P<0.01)。经一个月治疗后血浆Hcy水平与正常人比较无显著性差异(P>0.05),而血浆ET水平与正常人比较仍有显著性差异(P<0.05)。结论:检测AMI患者血浆Hcy和ET水平的变化对临床观察预后有重要的临床价值。

Objective To explore the clinical significance of changes of plasma Hey and ET levels in patients with AMI after treatment. Methods Plasma Hey and ET levels were measured with RIA in 33 patients with acute myocardial infarction both before and after treatment as well as in 30 controls. Results Plasma Hey and ET levels were significantly higher in the AMI patients than those in the controls before treatment and the levels wcre mutually positively correlated （ P 〈 0.01 ）. After treatment for one month, the plasma Hcy level in the patients were not much different from those in the controls （ P 〉 0.05 ）, but plasma ET levels, though dropped markedly remained significantly higher （P 〈 0.05）. Conclusion Changes of plasma Hcy and ET levels after treatment might be of prognostic importance in patients with acute myocardial infarction.