针刺大陵穴对大脑皮质的影响--MRI研究

Study on the mechanism of acupuncture at Daling (PC 7) for mental diseases by fMRI

目的:探讨针刺大陵穴治疗精神性疾病的中枢神经系统机制。方法:采用功能磁共振成像技术,观察针刺大陵后脑功能区变化。纳入8名健康志愿者作为受试对象,每名受试者在大陵穴接受针刺刺激,刺激模式为"休息-刺激-休息-刺激-休息",最终所获得的数据采用SPM2软件包分析其作用部位。结果:针刺大陵穴所获得的脑激活区主要位于额下回的Brodmann46/47/44/9区,额中回的Brodmann6区,颞上回的Brodmann22区,中央后回和顶下小叶的Brodmann40区。结论:额颞叶损伤、额叶功能低下或激活程度不够与精神性疾病的发病密切相关。针刺大陵穴对精神性疾病治疗作用的起效途径之一可能是通过激活中枢神经系统端脑额颞叶皮质完成的。

Objective To probe into the central nervous mechanism of acupuncture at Daling （PC 7） treating mental diseases by fMRI. Methods Eight healthy volunteers were enrolled in the study. Acupuncture stimulation was given at Daling （PC 7） in each subject with a stimulating pattern, ＂rest-stimulation-rest-stimulation-rest＂. The fMRI data were analyzed with SPM 2 software package. Results The activating areas of acupuncture at Daling （PC 7） were mainly on Brodmann 46/47/44/9 areas of inferior frontal gyrus, Brodmann 6 area of middle frontal gyrus, Brodmann 22 area of superior temporal gyrus and Brodmann 40 area of postcentral gyrus and inferior parietal lobule. Conclusion Pathogenetic factors of mental diseases are very complicated, damange or hypofunction or inadequate activation of frontal lobe and temporal lobe are closely related with mental diseases. Therefore, activating the frontal and temporal lobe possibly is one of the mechanisms of acupuncture at Daling （PC 7） treating mental diseases.