图形视网膜电图和图形视觉诱发电位同时记录青光眼及高眼压症的研究

PERG and PVEP simultaueously recorded in glaucoma and ocular hypertension

对30例50只青光眼、14例28只高眼压症进行PERG和PVEP同时记录。首次发现青光眼和高眼压症的RCT延长，同时青光眼组AP50、AP100下降、LP100延长，异常率分别为46％、52％、54％，高眼压症组AP50和LP100的异常率均为28.57％。青光眼组LP100、RCT与视野缺损、C／D大小呈正相关，AP100与视野缺损、C／D大小呈负相关，AP50与视野缺损呈负相关。本研究从电生理角度证实青光眼的主要损害部位为视网膜神经节细胞及其轴索。PERG和PVEP同时检测青光眼和高眼压症的异常率分别为70％和42．86％，高于单项检测者，同时记录对青光眼早期诊断及病情估计有重要参考价值。

Pattern Electroretinogram (PERG) and Pattern Visual Evoked Potential(PVEP) were simultaneously recorded in 30 glaucoma patients (50 eyes), 14 ocular hypertension(OHT) patients(28 eyes) and 35 normal subjects (70 eyes). It was observed that the average RCT was significantly longer in both glaucoma and OHT patients than the normal subjects. The average AP (abnormal rate: 46%), AP (abnormal rate: 54%)were significantly lower and the average LP(abnormal rate: 52%)was significantly longer in glaucoma than in the normal group. Abnormal rates of AP and LP were both 28. 57% in OHR. Abnormal rates found by simultaneously recording PERG and PVEP in glaucoma(70%) and OHT (42. 86%) patients were higher than those found by PERG or PVEP alone. LP and RCT had significantly positive relations with the visual field defects and cup/disc ratio (C/D) ;AP was negatively correlated with the visual field defects and C/D;there was negative correlations between AP and the visual field defects. It is demonstrated that retinal ganglion cell and it's axon are the places where glaucomatous impairment happens. PERG and PVEP simultaneously recorded are important to the early diagnosis and follow-up of glaucoma.