冠心宁治疗冠心病不稳定型心绞痛疗效观察

Clinical observation on unstable angina pectoris by the treatment of Perhexiline

目的:观察冠心宁治疗冠心病不稳定型心绞痛的临床疗效和安全性。方法:将确诊为冠心病不稳定型心绞痛的患者60例随机分成治疗组30例和对照组30例,治疗组在应用西药的基础上加用冠心宁注射液20mL加入5%葡萄糖注射液250mL中静点,对照组单纯应用西药,2周为1个疗程。观察心绞痛症状改善情况(包括心绞痛发作次数、持续时间,硝酸甘油服量)治疗前后心电图、24hHolter的变化情况。结果:治疗组总有效率90%,对照组总有效率73.3%,两组比较差异显著P<0.01。结论:冠心宁治疗冠心病不稳定型心绞痛疗效肯定、安全。

Objective： To observe the clinical curative effect and safety of unstable angina pectoris by the treatment of Perhexiline. Methods： 60 patients were randomly divided into treatment group and control group, treatment group were given Perhexiline injection 20mL which put in 5% Glucose on the base of western medicine. Control group were given western medicine only, two weeks as one course. Then observed the improving of angina （included the frequency of angina pectoris attacks, persistence time, dosage of Nitroglycerin）, ECG of prior treatment and post-treatment, the variance of 24h Hoher. Results： The total effective rate of treatment was 90.0%, control group was 73.3%. There was significant differences between the two groups, P〈0.01. Conclusion： Perhexiline can treat unstable angina oectoris safely and effectively.