前列腺素E_1联合腺苷钴胺治疗带状疱疹神经痛疗效观察

Clinical observation on Lipo PGE_1 in combination with cobamamide for neuralgia in patients with herpes zoster

目的:观察前列腺素E1脂微球载体制剂(Lipo PGE1)联合腺苷钴胺治疗带状疱疹神经痛的疗效和安全性。方法:66例带状疱疹神经痛患者随机均分为2组,对照组给予阿昔洛韦、阿米替林及半导体激光治疗,治疗组在对照组治疗的基础上,加用Lipo PGE1及腺苷钴胺治疗,疗程1周。结果:治疗组与对照组的有效率分别为84.8%、63.6%,两组比较有显著性差异(P<0.05);治疗后3月内随访,治疗组疼痛积分、带状疱疹后遗神经痛发生率显著低于对照组。结论:前列腺素E1脂微球载体制剂(Lipo PGE1)联合腺苷钴胺治疗带状疱疹神经痛安全、有效,并对后遗神经痛有较好的预防作用。

Objective ： To observe the efficacy and safety of combined therapy of Lipo PGE1 and cobamamide in the treatment of neuralgia in Herpes zoster. Methods ： 66 patients with neuralgia of Herpes zoster were randomly divided into 2 groups ： control group were treated with acyclovir, amitriptyline and semi-conductor laser, treatment group were administrated with Lipo PGE1 and cobamamide additionally based on the management of control group. The two groups were both treated for 1 week. Results： The effective rates （ER） for treatment group and control group were 84.8% and 63.6% respectively. Great significances were found between two groups （ P 〈 0.05 ）. Pain score and the incidence of postherpetic neuralgia of treatment group were lower than that of control group in 3 months after the treatment. Conclusion： Combined therapy of Lipo PGE1 and cobamamide is safe and effective for the treatment of neuralgia in Herpes zoster and can prevent postherpetic neuralgia in some degree.