摘要
目的对比观察胺碘酮、厄贝沙坦及其合用对大鼠心肌缺血再灌注损伤(MIRI)的保护作用及可能机制。方法将50只SD雄性大鼠随机分为5组,按实验要求预处理1周后,小动物呼吸机、心电监护下建立大鼠MIRI模型。测再灌注120min时血流动力学指标;取血测MDA含量、SOD活性;心肌染色后称取左室、缺血及梗死区重量。结果5组血流动力学指标差异无显著性(P>0.05);药物干预组再灌注心律失常、缺血范围、梗死范围、MDA含量、SOD活性与假手术组、缺血再灌注组有显著差异(P<0.05);联合用药组与单药组有显著差异(P<0.05)。结论胺碘酮、厄贝沙坦对MIRI有保护作用,联合用药有叠加效应。
Objective To compare the effects of Amiodarone ,Irbesartan and both combination on the prevention of myocardium ischemia/reperfusion injury.Methods 50 SD rats were randomly divided into five groups.After 1 week of pretreatment,all rats were subjectived to 30min of left anterior descending coronary occlusion and 2 hours of reperfusion with hemodynamic and electrocardiographic monitoring.In the end ,the parameter of hemodynamics and the level of serum SOD and MDA were observed,The tissue sections were stained and weighed.Results Hemodynamic variables were not significantly different among the five groups（P〉0.05）;The scores of arrhythmia of reperfusion ,myocardiol relative ischemia and infarct weight, the levels of serum SOD and MDA were significantly different among the five groups（P〈0.05）,was different between groups Amiodarone,Irbesartan and combined Amiodarone and Irbesartan（P〈0.05）too.Conclusion Aiodarone and Irbesartan have significant effects on rat model of myocardium ischemia reperfusion.There is additive effect when the two drugs were used in combination.
出处
《江西医药》
CAS
2008年第6期516-519,共4页
Jiangxi Medical Journal
