替罗非班对冠状动脉介入术中无复流的疗效

Effects of tirofiban in patients with no reflow during PCI procedure

目的观察替罗非班对冠状动脉介入无复流现象的治疗效果。方法冠状动脉介入术中出现无复流现象47例,依次给予硝酸甘油、维拉帕米和替罗非班,观察靶血管前向血流的TIMI分级。结果替罗非班明显改善TIMI血流,治疗无复流现象的有效率(33/40)优于硝酸甘油(5/47)和维拉帕米(2/42),差异有统计学意义(X2=72.216,P=0.000)。结论替罗非班对冠状动脉介入术中无复流现象有确切疗效。

Objectives To observe the clinical effect of platelet GP Ⅱ b/Ⅲ a receptor antagonist, tirofiban in patients with no reflow during percutaneous coronary intervention （PCI） procedure. Methods Forty-seven cases of no reflow patients during PCI procedure were infused with nitroglycerin, verapamil and tirofiban by turns, and the target vessel TIMI flow was graded accordingly. Results Tirofiban improved target vessel TIMI flow significantly than nitroglycerin and verapamil. Their effective proportions were 33/40, 5/47, 2/42, respectively. The differences were statistically significant （X^2 = 72.216, P= 0.000）. Conclusions Tirofiban has definite effect in patients with no reflow during PCI procure, and further investigation is necessary.