Th1/Th2漂移与高血压患者冠状动脉粥样硬化的关系及意义研究

Significance of the relationship between the imbalance of Th1/ Th2 and coronary atherosclerosis in patients with hypertension

目的:探讨Th1/Th2漂移与高血压患者冠状动脉粥样硬化的关系。方法:采ELISA法检测,对30例合并冠状动脉粥样硬化的高血压患者(简称AS组)、22例排除冠状动脉粥样硬化的高血压患者(简称EH组)和25例健康体检者的外周血血浆中IFN-γ和IL-4水平进行检测。结果:AS组IFN-γ水平显著增高,与EH组及健康组相比差异有统计学意义(P<0.01),EH组与健康组相比IFN-γ差异无统计学意义;三组间IL-4差异无统计学意义;AS组IFN-γ与IL-4比值较另两组增大。结论:Th1细胞活性亢进,导致Th1/Th2漂移,促进了高血压患者冠状动脉粥样硬化的发生。

Objective：To find out the significance of the relationship between the imbalance of Th1/Th2 and coronary atherosclerosis in patients with hypertension. Method： Peripheral blood was collected from 30 hypertensive patients with coronary atherosclerosis （ to abbreviate AS group） , 22 hypertensive patients without coronary atheroselerosis （to abbreviate EH group）and the control group consisting of 25 cases of health examinee. Plasma levels of IFN-γand IL-4 were measured by ELISA. Result： Plasma levels of IFN-γwere significantly increased in AS group compared with EH group and controls （P〈0.01） and there was no difference between in EH group and in controls. Among the three groups, however, the levels of IFN-γ and IL-4 were higher than those in EH group and in controls. Conclusion： The imbalance of Th1/Th2 , which resulted from the up-regulation of Thl cell function ,induced coronary atherosclerosis in patients with hypertension.