摘要
目的研究阿托伐他汀强化治疗对不稳定性心绞痛患者经皮冠状动脉介入术后高敏C-反应蛋白、肿瘤坏死因子α和白细胞介素-6及血脂水平的影响。方法选择2007年10月～2008年4月在我院行PCI术的60例不稳定性心绞痛患者为研究对象,随机分为三组:常规治疗组(20例):常规药物治疗;阿托伐他汀治疗组:在常规治疗基础上分别加用20mg(20例)和80mg(20例)阿托伐他汀治疗3d。分别于药物治疗前、药物治疗后3d(术前当天)及术后24h采集空腹静脉血,测定血清hs-CRP、TNFα、IL-6和血脂浓度。结果(1)常规治疗组与20mg阿托伐他汀组血清hs-CRP、TNFα和IL-6浓度治疗3d后均没有显著性变化,而在PCI术后则均有显著性升高(P<0.05)。(2)80mg阿托伐他汀治疗组治疗3d后hs-CRP、TNFα和IL-6浓度均呈明显降低(P<0.05),且经PCI术后亦无显著性升高。(3)三组治疗前、后的各血脂成份的变化差异均无显著性(P>0.05)。结论PCI术可以导致血清hs-CRP、TNFα和IL-6水平升高;阿托伐他汀(80mg)强化治疗3d后可明显控制PCI术后血清hs-CRP、TNFα和IL-6水平的上升,从而减少心血管事件的发生。
Objective To investigate the effect of high-dose atorvastatin on serum levels of high-sensitive c-reactive protein （hs-CRP）,tumor necrosis factor alpha （TNFα）, IL-6 and lipids in patients with unstable angina undergoing percutaneous coronary intervention（PCI）. Methods Sixty patients who underwent PCI from October 2007 to April 2008 in our hospital were randomized into three groups： control group（n=20） treated without lipid-lowering drugs;20mg（n=20） and 80mg（n=20） atorvastatin group with three days of treatment. The serum levels of hs-CRP,TNFα ,IL-6 and lipids were measured before and after three days treatment （in the early morning of PCI） and at 24 hours after PCI. Results （1）The treatments of 20mg atorvastatin did not decrease significantly the levels of hs-CRP,TNFα and IL-6. （2）Compared to the control group,the levels of hs-CRP, TNFα and IL-6 were decreased markedly by 80mg atorvastatin（P〈 0.05）. （3）No changes of lipid levels were observed in any group before and after treatment. Conclusion The result suggests that PCI can lead to a detectable increase in serum levels of hs-CRP,TNFα and IL-6 in patients with coronary heart disease; 80mg atorvastatin eould sighifieantly decrease the serum levels of hs-CRP,TNFα and IL-6 in patients with PCI in three days.
出处
《中国现代医生》
2008年第20期33-35,共3页
China Modern Doctor
