中药生精冲剂对精索静脉曲张大鼠的治疗

Shengjing Granule for Varicocele in Rats

目的:研究中药生精冲剂对大鼠精索静脉曲张的影响及疗效。方法:从80只SD雄性大鼠中随机抽出20只作为假手术组,余60只均建立精索静脉曲张病理模型后随机均分为模型组、生精冲剂组和克罗米芬组。造模后15d生精冲剂组和克罗米酚组分别给予生精冲剂4g/(kg.d)和克罗米芬20mg/(kg.d)灌胃,模型组和假手术组正常喂食。造模后45d放免法测定血清性激素(FSH、LH和T)及观察各组大鼠睾丸组织结构。结果:生精冲剂组大鼠光镜下睾丸组织结构优于模型组和克罗米芬组;血清FSH、LH生精冲剂组显著低于模型组和克罗米芬组(P<0.05),而克罗米芬组显著高于其他3组。T在生精冲剂组、克罗米芬组和假手术组之间无显著差异,但均显著高于模型组(P<0.05)。结论:中药生精冲剂对精索静脉曲张引起的睾丸损害有保护及修复作用,且可能优于克罗米芬。

Objective：To study the influence and therapeutic effect of the Chinese herbal drug Shengjing Granule on varicocele in rats.Methods：A total of 80 male Sprague-Dawley rats were equally randomized into a sham operation group and 3 varicocele model groups,and the latter 3 again subdivided into a model,a Shengjing and a Clomifene group.Fifteen days after the modeling,the Shengjing and the Clomifene groups were intragastrically given Shengjing Granule and Clomifene at the dose of 4 g /（kg·d）and 20 mg /（kg·d）,respectively,while the model and sham operation groups were on normal diet.Thirty days later,the effects of Shengjing Granule were assessed by determining such serum sexual hormones as FSH,LH and T and observing the morphological changes of the testes of different groups of rats under the light microscope.Results：The testis constitution was better and the levels of FSH and LH were significantly lower in the Shengjing group than in the model and Clomifene groups（P〈0.05）but markedly higher in the Clomifene group than in the other three.The T level showed no obvious difference among the Shengjing,Clomifene and sham operation groups but was significantly higher in the three groups than in the model group（P〈0.05）.Conclusion：Shengjing Granule can not only protect the testis from but also repair varicocele-induced injury,probably with a better efficacy than Clomifene.