快速成形技术制造组织工程支架研究进展

Current Progress of Fabricating Tissue Engineering Scaffold using Rapid Prototyping Techniques

支架作为组织工程的关键要素之一,影响着所接种细胞的分布和增值以及新组织的形成。传统的方法虽然可以制造出各种孔隙率的支架,但缺乏对支架多孔结构的控制。近年来,快速成形技术发展迅速,并成功应用于组织工程支架的制造,实现了组织工程支架内部多孔结构与复杂外形的精确控制,从而使得构建理想的组织工程化结构体成为可能。以下回顾了应用快速成形技术制造组织工程支架的优势与潜力,展望了未来组织工程支架的设计制造发展方向。

As one of the key factors for tissue engineering, scaffolds affect the spread and proliferation of seeded cells and the formation of new tissue. Although conventional methods can produce porous scaffolds with different porosities, they are lack controls the porous structures of the scaffolds. In recent years, rapid prototyping （RP） techniques have been developed and have successfully applied to fabricate TE scaffolds. RP techniques can provide accurate control over internal pore architectures and complex-shapes. As a result of these techniques, ideal tissue-engineered constructs could be prepared. This paper reviewed the advantages, potential and future directions of RP techniques in the design and fabrication of TE scaffolds.