乙型肝炎病毒前S_1抗原及抗体的检测及临床意义

Detection of preS 1 of HBV and anti preS 1 and Its Clinical Significance

用合成乙型肝炎病毒（ＨＢＶ）前Ｓ１肽及其免疫抗体制备的试剂，检测１９例急性、１０３例慢性乙型肝炎患者血清中的前Ｓ１抗原和抗体。结果：前Ｓ１抗原及抗体的阳性率在急性乙型肝炎患者分别为８４．２％和８９．５％，在慢性乙型肝炎患者分别为２５．０％和８４．２％。前Ｓ１抗原在血清学表达上与ＨＢＶＤＮＡ、ＨＢｅＡｇ的阳性符合率分别高达８９．３％和８７．５％。前Ｓ１抗体与抗ＨＢｓ在体内有明显相伴随关系。提示：前Ｓ１蛋白是ＨＢＶ在体内复制的可靠标志，而前Ｓ１抗体反映疾病的恢复和病毒的清除。

PreS 1 and anti preS 1 of HBV in sera of patients with acute (19 cases) and chronic (103 cases) hepatitis B were detected with synthetic preS 1 peptides and anti serum from the immunized mice. Results:The positive rates of preS 1 and anti preS 1 were 84.2% and 89.5 % in the acute hepatitis B and 25.0% and 84.2% in the cronic hepatitis B,respectively. The agreement rate of preS 1 with HBV DNA and HBeAg were 89.3% and 87.5% respectively. The anti preS 1 was positively related with anti HBs. These results suggest that preS 1 is the reliable marker of HBV replication, whereas anti preS 1 reflects convalensce of the patients with HB and clearance of HBV.