神经组织工程生物材料的生物相容性及安全性评价

Biocompatibility and safety of nerve tissue engineering biomaterials

神经组织工程生物材料的出现尽管只有20年左右的时间,但发展迅速,已成为神经系统疾病的一种新的治疗手段和发展趋势。多数组织工程生物材料在动物实验已体现出良好的生物相容性,但是由于神经系统独特性,实际应用于临床还需要大量深入研究。总之,具有良好生物相性和安全性的神经组织工程生物材料仍是当前和今后研究方向。文章回顾神经组织工程生物材料的应用历史及现状,从生物相容性及安全性方面对现有神经组织工程生物材料进行评价,为提高神经组织工程生物材料水平提供依据。

Although the biomaterials has emerged in the field of nerve tissue engineering for only 20 years, they develop rapidly and are considered as a new treatment method for nervous system disease. Most of tissue engineering biomaterials are well biocompatible to animals, but the clinical application deserves more investigations. In a word, it is potential to study on the biocompatibility and safety of nerve tissue engineering. This paper reviews the application and current status of the biomaterials of nerve tissue engineering and evaluates the available biomaterials regarding the biocompatibility and safety, thus providing evidences for improving the biomaterials of nerve tissue engineering.