期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

TGF-β/Smads信号转导通路与创面愈合研究进展 被引量：5

下载PDF
导出
摘要 信号转导是创伤愈合研究中探索外界因素与内在因素联系的关键。文章介绍了TGF-β蛋白家族、Smad蛋白家族及其结构、Smad介导的TGF-β信号转导的基本过程和TGF-β/Smads信号转导在创面愈合中的作用及其进展。
作者 肖秀丽 王振宜 唐汉钧
机构地区 上海市宝山区中医医院 上海中医药大学附属岳阳中西医结合医院 上海中医药大学附属龙华医院
出处 《中国中西医结合皮肤性病学杂志》 CAS 2008年第3期196-199,共4页 Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine
关键词 TGF-Β SMADS 信号转导 创面愈合
分类号 R751.05 [医药卫生—皮肤病学与性病学]
  • 相关文献

参考文献22

  • 1[1]Singh J,Ling LE,Sawyer JS,et al.Transforming the TGF-β path way:convergence of distinct lead generation strategies on a novel ldnase pharmacophore for TβR I (ALKS)[J].Curr Opin Drug Discov Devel,2004,7:437-445.
  • 2[2]Lasky JA,Ortiz LA.Antifibrotic therapy for the treatment of pulmonary fibrosis[J].Am J Med Sci,2001,322:213-222.
  • 3[3]Yu Q,Stamenkovic L Cell surface -localized matrix metalloproteinase-9 proteolytically activates TGF-beta and pro-motes truant invasion and angingenesis[J].Genes Dev,2000,14:163-176.
  • 4[4]Attisano L,Miller,B.Role of transforming growth factor beta and Wnt signalling pathways in colon cancer[J].Cur Opin Cell Biol,2000,12:235.
  • 5[5]Massague J.TGF-beta signal tranednction[J].Annu Rev Biochem,1998,67:753.
  • 6[6]Kim J,Johnson K,Chen HJ,et al.Drosophila Mad binds to DNA and directly mediates activation of vestigial by decapentaplegic[J].Nature,1997,388:304-308.
  • 7[7]Fortuno ES,Le-Sueur JA,Graft JM.The amino terminus of Smads permits transcriptional specificity[j].Dev Biol,2001,230:110-124.
  • 8[8]Chen YG,Massague J.Smadl recognition and activation by the ALK1 group of transforming growth factor-beta family receptors[J].J Biol Chem,1999,274:3672-3677.
  • 9[9]Engel ME,McDonnell MA,Law BK et al.Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription[J).J Biol Chem,1999,274:37-43.
  • 10陈伟,付小兵,孙同柱,孙小庆,盛志勇.溃疡组织中转化生长因子-β异构体与其受体含量的变化及其对创面修复的影响[J].中国危重病急救医学,2002,14(2):93-95. 被引量：20

二级参考文献39

  • 1Monaco JL, Lawrene WT. Acute wound healing an overview. Clin Plast Surg, 2003,30:1 - 12.
  • 2Ten Dijke P, Goumans MJ, hoh F, et al.Regulation of cell proliferation by Smad proteins. J Cell Physiol, 2002, 191:1 -16.
  • 3Kretzschmar M. Transforming growth factor-β and breast cancer: transforming growth factor - β/SMAD signaling defects and cancer. Breast Cancer Res, 2000, 2:107 - 115.
  • 4Hashimoto O, Ueno T, Kimura R, et al. Inhibition of proteasome - dependent degradation of Weel in G2 -arrested Hep3B cells by TGF beta 1. Mol Carcinog, 2003, 36 : 171 -182.
  • 5Verrecchia F, Mauviel A. Transforming growth factor - beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation. J Invest Dermatol, 2002, 118:211 -215.
  • 6Sumiyoshi K, Nakao A, Setoguchi Y, et al. Smads regulate collagen gel contraction by human dermal fibroblasts. Br J Dermatol, 2003, 149:464 -470.
  • 7Barna G, Sebestyen A, Chinopoulos CC, et al. TGF beta 1 kills lymphoma cells using mitochondrial apoptotic pathway with the helpof caspase - 8. Anticancer Res, 2002, 22 :3867 - 3872.
  • 8Jang CW, Chen CH, Chen CC, et al. TGF- beta induces apoptosis through Smad - mediated expression of DAP - kinase. Nat Cell Biol, 2002, 4:51 - 58.
  • 9Valderrama Carvajal H, Cocolakis E, Lacerte A, et al. Activin/TGF - beta induce apoptosis through Smad - dependent expression of the lipid phnsphatase SHIP. Nat Cell Biol, 2002, 4:963 - 969.
  • 10Ashcroft GS, Roberts AB. Loss of Smad3 modulates wound healing. Cytokine Growth Factor Rev, 2000, 11 : 125 - 131.

共引文献42

同被引文献119

引证文献5

二级引证文献33

中国中西医结合皮肤性病学杂志
2008年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部