DADLE模拟冬眠对休克大鼠血流动力学的影响

Hemodynamic Effect of DADLE Which can Mimics Hibernation on Duration of Survival during Hemorrhagic Shock

目的:探讨DADLE(冬眠诱导触发物类似物)对失血性休克大鼠血压和心功能的影响。方法:36只健康雄性SD大鼠,随机分成假手术对照组、休克对照组和DADLE实验组(分成1mg/kg组和5mg/kg组),制成失血性休克大鼠模型,监测复苏后3小时内各时点动脉血压(MAP)和心功能指标(±dp/dtmax)。结果:DADLE实验组(包括1mg/kg组和5mg/kg组)复苏后5分钟MAP和±dp/dtmax开始升高,30分钟达高峰,复苏后同一时点各项指标均显著高于休克对照组(P<0.05),其中1mg/kg组和5mg/kg组没有显著差异。结论:DADLE能改善失血性休克大鼠的血压和心功能。

Objective： To investigate the hemodynamic effect of DADLE on rats with hemorrhagic shock. Methods： A model of rat with hemorrhagic shock was established in 36 healthy male SD rats. The rats were randomly divided into sham group,sterile water-treated group and DADLE-treated group （divided into 1 mg/kg group and 5 mg/kg group）. All animals were observed for 3 hours after resuscitation and MAP,＋dP/dtmax were recorded every time point. Result： After hemorrhagic shock and resuscitation,MBP, ＋dP/dtmax had no significant change in the sterile water-treated group, and remained descended after resuscitation. All hemodynamic datas inceased rapidly after DADLE （1 mg/kg or 5mg/kg）was administrated. The data reached a zenith at 30 minutes after resuscitation. The data were significantly different from the sterile water-treated group （P 〈 0.05）. There was no significant difference between 1 mg/kg or 5 mg/kg DADLE-treated groups. Conclusion： DADLE can improve the hemodynamic data during the course of hemorrhagic shock.