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符合罗马Ⅲ标准的功能性消化不良患者固体胃排空功能研究 被引量:23

Solid Gastric Emptying Function in Patients with Functional Dyspepsia Fulfilling Rome Ⅲ Criteria
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摘要 背景:罗马Ⅲ标准对功能性消化不良(FD)的定义作了更新和修订,相应FD患者人群亦发生改变。目的:研究符合罗马Ⅲ标准的FD患者的固体胃排空功能,以及新的FD症状谱和分型与固体胃排空功能之间的关系。方法:对36例符合罗马Ⅲ标准的FD患者和32名健康志愿者行99Tc固体胃排空试验。比较不同症状分型FD患者的固体胃排空功能,分析固体胃排空功能与罗马Ⅲ标准中FD症状的相关性。结果:10例(27.8%)FD患者固体胃半排空时间超过正常上限,9例(25.0%)2h残留率高于正常上限。餐后不适综合征(PDS)、上腹痛综合征(EPS)和PDS+EPS型FD患者固体胃半排空时间分别为(150.3±40.2)min、(118.3±25.1)min和(150.5±51.2)min,三组间差异无统计学意义(P=0.126)。餐后饱胀不适症状与固体胃半排空时间和2h残留率均呈线性正相关,相关系数分别为11.5(P=0.043)和0.045(P=0.040)。结论:本组27.8%的FD患者存在固体胃排空延迟。PDS和PDS+EPS型FD的固体胃半排空时间有长于EPS的趋势。FD患者的餐后饱胀不适症状与固体胃排空延迟有关,固体胃排空延迟是符合罗马Ⅲ标准的FD患者的病理生理机制之一。 Background: In Rome Ⅲ criteria, the definition of functional dyspepsia (FD) was updated and revised, which had resulted in the alteration of FD population. Aims: To investigate the solid gastric emptying function in FD patients fulfilling Rome Ⅲ criteria and the correlation of solid gastric emptying function with symptoms and diagnostic categories of FD. Methods: Thirty-six FD patients fulfilling Rome Ⅲ criteria and 32 healthy volunteers were enrolled in this study. The solid gastric emptying function was determined by ^99Tc-labeled scintigraphic method and was mutually compared among FD patients with different diagnostic categories. The correlations of solid gastric emptying function with FD symptoms in Rome Ⅲ criteria were analyzed. Results: Ten (27.8%) FD patients had a longer solid gastric half emptying time than upper limits of normal, while 9 (25.0%) had a higher residue rate of 2 hours than upper limits of normal. The solid gastric half emptying time of patients with postprandial distress syndrome (PDS), epigastric pain syndrome (EPS), and PDS+EPS were (150.3±40.2) min, (118.3±25.1) min, and (150.5±51.2) min, respectively, no significant difference was found between these three groups (P=0.126). Bothersome postprandial fullness was positively correlated with both solid gastric half emptying time and residue rate of 2 hours, the correlation coefficients were 11.5 (P=0.043) and 0.045 (P= 0.040), respectively. Conclusions: Delayed solid gastric emptying was present in 27.8% of FD patients enrolled in this study. Patients with PDS and PDS+EPS appear to have a longer solid gastric half emptying time than EPS. Bothersome postprandial fullness is correlated with delayed solid gastric emptying in FD patients. Delayed solid gastric emptying is one of the pathophysiologic mechanisms in FD patients fulfilling Rome III criteria.
出处 《胃肠病学》 2008年第9期528-531,共4页 Chinese Journal of Gastroenterology
关键词 罗马Ⅲ标准 消化不良 功能性 胃排空 体层摄影术 发射型计算机 单光子 诊断 Rome Ⅲ Criteria Dyspepsia, Functional Gastric Emptying Tomography, Emission-Computed, Single-Photon Diagnosis
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  • 1Tack J. Talley NJ, Camilleri M, et al. Functional gastroduodenal disorders. In: Drossman DA, Corazziari E, Delvaux M, et al eds. Rome Ⅲ: The Functional Gastrointestinal Disorders. 3rd ed. McLean: Degnon Associates, 2006. 419-486.
  • 2谷成明,柯美云.胃动力功能检测技术及其评价:核素胃排空测定方法.见:周吕,柯美云主编.神经胃肠病学与动力:基础与临床.北京:科学出版社.2005.511-514.
  • 3Quartero AO, de Wit N J,Lodder AC. et al. Disturbed solid-phase gastric emptying in functional dyspepsia: a meta-analysis. Dig Dis Sci, 1998.43 (9): 2028-2033.
  • 4Samelli G, Caenepeel P, Geypens B, et al. Symptoms associated with impaired gastric emptying of solids and liquids in functional dyspepsia. Am J Gastroenterol, 2003, 98 (4): 783-788.
  • 5Stanghellini V. Tosetti C, Paternico A, et al. Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia. Gastroenterology, 1996. 110 (4): 1036-1042.
  • 6Talley N J, Verlinden M, Jones M. Can symptoms discriminate among those with delayed or normal gastric emptying in dysmotility-like dyspepsia? Am J Gastroenterol, 2001, 96 (5): 1422-1428.
  • 7Moayyedi P, Soo S, Deeks J, et al. Phanuaeologieal interventions for non-ulcer dyspepsia. Coehrane Database Syst Rev, 2006. 18 (4): CD001960.
  • 8Tack J, Bisschops R, Sarnelli G. Pathophysiology and treatment of functional dyspepsia. Gastroenterology, 2004, 127 (4): 1239-1255.
  • 9蓝宇,柯美云,朱朝晖,李方,谷成明.糖尿病不同阶段胃运动功能的临床研究[J].中华消化杂志,2001,21(12):716-719. 被引量:39
  • 10Camilleri M. Clinical practice. Diabetic gastroparesis. N Engl J Med, 2007, 356 (8): 820-829.

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