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盐酸金刚乙胺的合成 被引量:4

Synthesis of Rimantadine Hydrochloride
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摘要 1-金刚烷甲酸经酰氯化后与丙二酸二乙酯乙氧基镁反应得到金刚烷甲酰丙二酸二乙酯,再经水解脱羧、肟化、还原、成盐等反应得到抗病毒药盐酸金刚乙胺,总收率约70%。 Rimantadine hydrochloride was synthesized from 1-adamantanecarboxylic acid chloride via reaction with diethyl ethoxymagnesium malonate to give diethyl adamantaneformyl malonate, which was subjected to hydrolytic decarboxylation, oximation, reduction and then salt formation with an overall yield of about 70 %.
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2008年第10期725-726,共2页 Chinese Journal of Pharmaceuticals
关键词 盐酸金刚乙胺 抗病毒药 合成 rimantadine hydrochloride antiviral drug synthesis
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参考文献9

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二级参考文献25

  • 1王爱霞,邓伟吾,刘又宁,何礼贤,陆权,林江涛,郭元吉,钱桂生.流行性感冒临床诊断和治疗指南(2004年修订稿)[J].中华结核和呼吸杂志,2005,28(1):5-9. 被引量:82
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