四溴双酚-A的甲状腺激素干扰活性研究进展

Thyroid Hormone Disrupting Activities of Tetrabromobisphenol-A:a Review

四溴双酚-A(TBBPA)因与甲状腺激素的结构相似而被认为具有潜在的甲状腺激素干扰活性。目前已获得了TBBPA 具有甲状腺激素干扰效应的体内外实验证据,并推测 TBBPA 可能通过载体和核受体介导两种机制干扰生物体甲状腺激素系统;TBBPA 的活性氧诱导能力是其甲状腺激素干扰活性的表现,同时,TBBPA 的甲状腺干扰活性与神经毒性和生殖毒性等也具有密切关系,今后需进一步加强 TBBPA 对水生和两栖动物甲状腺激素干扰的活体实验研究。

Tetrabromobisphenol A （TBBPA） is supposed to have potential thyroid disrupting activities due to its similar structure to thyroid hormones. TBBPA has been proved to show thyroid disrupting effects in vivo and in vitro studies. TBBPA might disrupt thyroid hormone system through transthyretin- and thyroid receptor-mediated pathways. The ability of TBBPA inducing the production of reaetive oxygen species might be the extension of its thyroid disrupting activities. The thyroid disrupting effects of TBBPA might be closely related to its oxidative stress, reproduction toxicity and neurotoxicity. More experiments are required for the effeets of TBBPA on the aquatic and amphibian animals.