低分子肝素钙治疗不稳定型心绞痛的疗效观察

Clinical Observation for The Low Molecular Weight Heparin Calcium Treating Unstable Angina Pectoris

目的观察低分子肝素钙治疗不稳定型心绞痛的临床疗效。方法83例患者随机分为治疗组42例、对照组41例,常规给予硝酸酯类、β—受体阻滞剂、长效钙拮抗剂、阿司匹林、他汀类药物治疗。治疗组加用低分子肝素钙4100IU,腹部皮下注射每12h1次,共10d,观察心绞痛缺血性心电图的变化。结果治疗组心绞痛改善,心电图ST—T段改善,明显高于对照组(P<0.05)。结论低分子肝素钙治疗不稳定型心绞痛疗效显著,安全性高。

objective To observe the clinical effects of the low molecular weight heparin calcium on patients with unstable angina pecto- ris. Methods 83 patients were randomly divided into two groups, one therapy group（42 patients）and one control group（41 patients）. All 83 patients were treated by nitrate esters, β - receptor blocking drugs, long effect calcium antagonists, aspirin, statins, and so on. The therapy group were treated additionally with （4100IU）/12 h the low molecular weight heparin calcium given by abdominal wall subcutancous injection. The treatment course was 10 day. The symptoms of angina peetoris and the changes of ischemic ECG were col- lected and studied. Result The improvement of angina peetoris and ST- T Segment elevation in ECG of the therapy group were significantly different from that of control group （ P 〈 0.05 ）. Conclusion The therapy effects is good to unstable angina pectoris by giving the low molecular weight heparin calcium.