MICA分子及其在肾移植排斥反应中的作用
摘要
MICA分子是非经典的HLA—Ⅰ类基因MICA编码的膜结合蛋白，为应激诱生性抗原，具高度多态性，主要表达于上皮细胞、血管内皮细胞和成纤维细胞的表面。MICA分子不但与某些肿瘤、感染及自身免疫性疾病相关，而且可能在肾移植的排斥反应中发挥重要作用。MICA通过与其受体NKG2D的特异性结合而启动体液免疫和细胞免疫，参与移植肾的急慢性排斥反应，导致移植物失功。
出处
《国际泌尿系统杂志》
2008年第6期781-784,共4页
International Journal of Urology and Nephrology
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