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氰酸钠法合成磺酰脲类除草剂苄嘧磺隆 被引量:4

Synthesis of Herbicide Bensulfuron-methyl by Sodium Cyanate Method
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摘要 研究了以邻甲酸甲酯苄基磺酰氯、2-氨基-4,6-二甲氧基嘧啶和氰酸钠为原料,乙腈为溶剂,在吡啶催化下合成除草剂苄嘧磺隆的新方法。考察了溶剂种类、催化剂用量、氰酸钠用量、反应时间、反应温度等因素对反应的影响。结果表明:邻甲氧羰基苄基磺酰氯、2-氨基-4,6-二甲氧基嘧啶、吡啶和氰酸钠摩尔比为1∶1∶1∶1.2,乙腈为溶剂,在40°C下搅拌反应3 h,产品收率67.8%,纯度97.0%(HPLC)。该方法避免了剧毒光气,简化了工艺路线,是一个对环境友好的磺酰脲除草剂的合成方法。 Herbicide bensulfuron-methyl was prepared by reaction of methyl 2-(chlorosulfonylmethyl) benzoate with sodium cyanate and 2-amino-4, 6-dimethoxypyrimidine in the presence of pyridine as a catalyst in acetonitrile. The effects of kind of solvent, amounts of catalyst and sodium cyanate, reaction time and reaction temperature were studied. The optimum conditions are as follows: molar ratio of methyl 2-(chlorosulfonylmethyl) benzoate : g-amino-4,6-dimethoxypyrimidine : pyridine : sodium cyanate=1 : 1 : 1 : 1.2, acetonitrile as a solvent, reaction time 3 h, reaction temperature 40℃. The yield and purity of product is 67.8%, and 97% (HPLC), respectively. The method can secure from using phosgene and the process is simple. It is a green chemical method for preparation of sulfonylurea herbicides.
作者 王岩 张伟
出处 《化学世界》 CAS CSCD 北大核心 2008年第11期685-687,共3页 Chemical World
关键词 除草剂 苄嘧磺隆 合成 氰酸钠 herbicide bensul uron-methyl synthesis sodium cyanate
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