腹内高压对猪血流动力学影响的实验研究

Experimental Study on Hemodynamics Affected by Intra-abdominal Hypertension in Pig

目的:研究腹内压升高对猪血流动力学的影响。方法:将22只家猪随机分为两组,运用CO2气腹法制作猪腹内高压动物模型,建立气腹后分别在20、30 mmHg压力值下于不同时点测定血流动力学参数[平均动脉压(MAP),中心静脉压(CVP),心输出量(CO),心指数(CI)]参数的变化。结果:两组动物在不同时点的MAP、CVP、CO、CI等比较无显著性差异。结论:腹内高压对猪血流动力学无明显影响。

Objective：To investigate the effect of intra-abdominal hypertension（IAH） on hemodynamics in pigs.Methods：Twenty-two pigs were randomly divided into two groups（both n = 11）：IAH-30 group（intraabdominal pressure 30 mmHg）,and IAH-20 group（intra-abdominal pressure 20 mmHg）.Pig model of IAH was established by injection of carbon dioxide into the peritoneal cavity.Then,the changes in hemodynamic parameters[including mean arterial pressure（MAP）,central venous pressure（CVP）,cardiac output（CO）and cardiac index（CI）]were recorded at different time intervals at intra-abdominal pressure of 20 and 30 mmHg.Results：There were no significant changes in hemodynamic parameters including MAP,CVP,CO and CI at different time intervals between two groups.Conclusion：IAH has no significant effects on hemodynamics in pigs.