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生长激素在辅助生殖技术中的应用及作用机制 被引量:7

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摘要 生长激素(GH)在生殖过程中具有重要生理作用,辅助生殖技术中应用生长激素对诱导排卵有确切的治疗作用,有助于改善卵巢的反应性和卵细胞及胚胎的质量,提高妊娠率。体外及体内实验也证实生长激素可作用于卵巢,影响配子形成和甾体合成,促进小卵泡的生长并阻止其闭锁,有利于卵泡和配子的成熟,其在早期胚胎分化和代谢中也发挥重要作用,也可促进精子发生,就这些方面做一综述。如何选择最适宜治疗的患者群体及增加卵巢敏感性所需生长激素的最小剂量尚需进一步研究,生长激素作用机制及其是否通过胰岛素样生长因子I影响卵泡发育也需进一步探讨。
出处 《国际生殖健康/计划生育杂志》 CAS 2008年第6期351-354,共4页 Journal of International Reproductive Health/Family Planning
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