肌纤维母细胞瘤的病理学研究─附3例报告及文献复习

Pathologic study of myofibroblastoma: a report of 3 cases and review of literature

肌纤维母细胞瘤是一种可发生于成人及儿童的不常见肿瘤，其病因、临床、病理组织学特征及预后尚不十分清楚或有争论。本文报告3例病例，年龄4．5岁至62岁。2例位于腹腔，1例在头皮。组织学由具有平滑肌细胞和纤维母细胞特征的梭形肿瘤细胞、大量慢性炎细胞及粘液血管样背景构成。免疫组化SMActin、desmin、vimentin呈阳性表达。电镜下可见肌纤维母细胞特征。本文还就其良恶性及鉴别诊断进行了讨论。

Myofibroblastoma is an uncommon tumor in adults and children, and little is known about its etiology,prognosis, clinical and pathologic characteristics. We reported 3 cases whose ages ranged from 4. 5~62 years.Sites of involvement included mesentery (2 cases) and scalp (1 case). Histologic examination consisted of spindle cells, chronic inflammatory cells and myxoid background with delicate vasculature. Immunohistochemical stains demonstrated actin, desmin and vimentin positivity. Ultrastructural studies also disclosed myofibroblastic features. In addition, prognosis and histologic differential diagnosis of the tumor were discussed.