头穴透刺对脑性瘫痪患儿血清白细胞介素-6、肿瘤坏死因子-α水平的影响

Influence of Scalp Acupuncture on Serum levels of Interleukin-6,Tumor Necrosis Factor Alpha in Children with Cerebral Palsy

目的探讨头穴透刺对脑性瘫痪(CP)患儿血清IL-6、TNF-2水平的影响。方法选择CP患儿160例,随机分为透刺组和西药组。透刺组80例,采用头部腧穴透刺治疗,百会透太阳穴;西药组80例,采用静脉滴注神经营养药物;另选门诊正常体检儿童50例为健康对照组。采用放射免疫分析法检测各组儿童血清IL-6、TNF-α水平。用Gesell发育量表对CP患儿进行治疗前后发育龄各能区(应物能、动作能、言语能、应人能)发育商水平进行动态评估。结果透刺组治疗后显效48例,有效30例,无效2例,总有效率为97.5%;西药组显效25例,有效32例,无效23例,总有效率为71.25%,二组总有效率比较有显著性差异(Z=-7.276P<0.05)。透刺组治疗后发育商DQ值为(68.04±15.54)分,西药组为(57.94±12.84)分,二组比较有显著性差异(P<0.01)。透刺组治疗后IL-6水平为(91.26±32.19)ng/L,西药组为(130.53±31.24)ng/L,二组比较有显著性差异(P<0.01)。透刺组治疗后TNF-α水平为(0.93±0.33)ng/L,西药组为(1.20±0.40)ng/L,二组比较有显著性差异(P<0.01)。结论头穴透刺是促进CP患儿康复的有效治疗方法之一,可调节CP患儿的神经免疫功能。

Objective To explore the influence of scalp acupuncture on interleukin - 6 （ IL - 6 ）, tumor necrosis factor - α （ TNF - α ） of children with cerebral palsy（CP）. Methods One hundred and sixty patients with CP were chosen who were randomly divided into 2 groups. Scalp acupuncture group （n = 80 ） with head aeupoints through thorn treatment ： Baihui through Taiehong; medicine treatment group （n = 80） were applicated with static point nutrition nerve drug therapy ;50 healthy children who were examined in out - patient department at the same time were selected as healthy control group. IL - 6 and TNF - α were determined using radioimmunoassay method of detection. Gesell develop- ment schedules were performed for the treatment of children with CP before and after the energy region （ social area, adaptive area, language area,motion area） to the level of development of the dynamic assessment. Results The overall efficacy of scalp acupuncture group after treatment showed 48 cases were very effective,30 cases were effective,and 2 cases invalid, the total efficiency was 97.5%. Medicine treatment group showed 25 cases were very effective,32 cases were effective and 23 cases invalid,the total efficiency was 71.25%. There was a significant difference of the total efficiency between the 2 groups （Z = - 7. 276 P 〈 0.05）. The DQ in the scalp acupuncture group after treatment was （68.04 ± 15.54 ）score, and the medicine treatment group was （ 57.94 ± 12.84）score, and the difference of the 2 groups was remarkedly significant （ P 〈 0.01 ）. The IL - 6 in the scalp acupuncture group after treatment was （91.26 ± 32.19） ng/L, and in the medicine treatment group was （ 130.53 ±31.24） ng/L,and the difference of the 2 groups was remarkedly significant （P 〈0.01 ）. The TNF - ct in scalp acu- puncture group afler treatment was （ 0.93 ± 0.33 ） ng/L,in the medicine treatment group was （ 1.20 ± 0.40） ng/L, the difference of the 2 groups was significant （ P 〈 0.01 ）. Conclusions Scalp acupuncture is an effective treatment to rehabilitate children with CP, and can adjust the neural immune function of children with CP.