猪干扰素-γ的研究进展

The Advance in Porcine Interferon-gamma

干扰素-γ(Interferon-gamma,IFN-γ)是在特定的诱生剂作用下,由机体自身产生的一种维持机体自我稳定的防御性物质,是一种具有抗病毒、抗肿瘤和免疫调节作用的细胞因子,主要由活化的T细胞和NK细胞产生。由于其免疫调节、抗病毒和抗肿瘤的独特作用,在动物传染性疾病的预防和治疗中具有广阔的应用前景。对猪干扰素-γ产生、分子结构、检测、生物学活性及作用机制以及应用等方面做以下简要综述。

Induction of formation of interferon-gamma production by specific inducting agent,as a kind of defense chemicals for maintains the stability of body generated by body self,is mainly secreted by NK cells and T cells.Due to the unique effect of anti-virus,anti-tumor and immune system,IFN-γ has a broad prospect of application in prevention and therapy of animal＇s infectious diseases.This article summarized porcine interferon-gamma briefly in following aspects,including production,structural characteristic,detection,biological activity,physiological mechanism and application.