甘露醇静脉注射对兔外周静脉及周围组织的影响

The Effect of Mannitol on Peripheral Veins in the Rabbit

观察了静推２０％甘露醇对兔耳缘静脉的影响，病理检查显示，注射２次时，甘露醇与生理盐水组无明显差别，注射４次及８次时，在穿刺部位及距穿刺点１ｃｍ处，甘露醇组血管及其周围组织病理损害加重。主要表现为血管壁增厚，内皮细胞破坏，血管内瘀血，周围组织炎症及水肿等。注射８次后５天与１０天的结果显示，两组恢复程度基本一致，即周围组织炎症及水肿的消失。研究结果提示，甘露醇易导致血管损害且不易恢复，因此不宜在同一部位反复注射，其机制可能与甘露醇的高渗性有关。

Influence of 20% mannitol injection on veins of rabbit's ear edge was observed in this study .Pathological results showed that there were differences between mannitol and normal saline after the second injection.After the forth and the eighth injection,pathological harms in blood tubes at punctures and peripheral tissues that were within a radius of 1cm aggravated.It mainly expressed in thickened tube walls,damaged endothenium,stasis vasclium,inflammatory and edematous peripheral tissues.After the eighth injection,natural recupreative results 5-10 days later showed that the degree of reinstatement in two group was in accordance,inflammation and edema in peripheral tissues were disappeared,The results suggested that mannitol is apt to damage vascular and not easy to revert.Therefore it shoud be avoided to inject at same point repeatedly,the mechanism might have relation with hyperosmosis of mannitol. Auther's address Department of Neurology,Jinan Military General Hospital,Jinan 250031