厄贝沙坦与非洛地平联用对高血压病左室肥厚的逆转作用

Effect of irbesartan combined with felodipine on reversing left ventricular hypertrophy in patients with essential hypertension.

目的探讨厄贝沙坦与非洛地平联合用药对原发性高血压(EH)患者左室肥厚(LVH)的逆转作用。方法EH伴LVH患者60例随机分为对照组(非洛地平5mg/d,30例)和治疗组(厄贝沙坦150mg/d加非洛地平5mg/d,30例),治疗2周时若血压仍>160/95mmHg(1mmHg≈0.133kPa),非洛地平分别增加1倍,总疗程共6个月。结果两组治疗后均能显著降低左室重量指数(LVMI)(P<0.01),且治疗组较对照组更为显著(P<0.01);两组治疗前平均收缩压、平均舒张压比较无统计学意义(P>0.05),治疗后较治疗前显著降低(P<0.01),但治疗后两组间无统计学意义(P>0.05)。结论厄贝沙坦与非洛地平联用逆转EH患者LVH效果较单用非洛地平疗效更为显著。

Objective To study the effects of irbesartan with felodipine on reversing left ventriclar hypertrophy（LVH）in patient with essential hypertension（ EH）. Methods Sixty patients with EH were divided randomly into two groups：the controlled group（felodipine 5rag/d, n = 30）and the treatment group（ irbesartan 150mg/d with felodipine 5rag/d, n = 30） . If the blood pressure 〉 160/95 mmHg was remained after two sweeks therapy, the dosage will be doubled and the therapy will be lasted for 6 months. Results Following therapy for 6 months, left ventricular mass index （LVMI } decreased significantly in the treatment group（ P 〈 0.01 ）. LVMI in the test group de- creased more than that in the contrlied group（P 〈0.01）.There were no differences for the mean systolic pressure（DBP）and mean diastolic pressure （SBP） pre-therapy in two groups （ P 〉0.05）. Following therapy for 6 months, SBP and DBP/24h decreased significantly （ P 〈 0.01 ）. but there were no difference between the two groups （ P 〉 0.05 ）. Conclusion The results suggest than irbesartan combined with felodipine is able to increase the effect on reversing LVH in patients with EH.