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枳椇子水提取液治疗非酒精性脂肪性肝炎的实验研究 被引量:8

Experimental Study on the Water Extract of Raisin Tree Seed in Treatment of Non-alcoholic Steatosis Hepatitis
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摘要 目的:观察枳椇子水提取液对实验大鼠非酒精性脂肪性肝炎(NASH)的治疗作用。方法:用高脂饲料诱导非酒精性脂肪性肝炎大鼠模型8周后,灌服枳椇子水提取液治疗2周,观察对模型大鼠肝脏病理脂肪变、炎症程度及血清ALT、AST、TNF-α、IL-8、FFA、胰岛素敏感性指标(ISI)和肝组织MDA、SOD的影响,并与凯西莱联合易善复治疗进行比较。结果:枳椇子能明显减轻模型大鼠肝脏炎症和脂肪变程度(P<0.01);降低血清ALT、AST、TNF-α、IL-8、FFA、肝组织MDA、SOD、提高ISI(P<0.01或P<0.05)。除肝组织MDA、SOD外,其它指标均明显优于对照组(P<0.05)。结论:枳椇子水提取液对高脂饲料诱导的大鼠NASH有明显的治疗作用,效果优于凯西莱联合易善复治疗,其作用机制可能与提高胰岛素敏感性、抗氧化、抑制炎症细胞因子等有关。 Objective:To observe the therapeutic efficacy of the water extract of raisin tree seed on non-alcoholic steatosis hepatitis (NASH) in rats. Methods:NASH rat model was established after an 8-week high fat diet. NASH rats were gavaged with the water extract of raisin tree seed for 2 weeks. Fatty change and inflammation in the liver was observed pathologically and serum alanine aminotransferase( ALT), aspartate aminotransferase(AST) , tumor necrosis factor α ( TNF-α), interleukin 8 ( IL-8), fatty acid, insulin sensitivity index ( ISI), and malondialdehyde (MDA) and superoxide dismutase (SOD) in liver tissue were measured or calculated after the administration. Another group treated with Tiopronin combined with Essentiale Forte served as the control group. Results:The extract of raisin tree seed dramatically improved the fatty change and inflammation in the liver (P〈0.01), decreased ALT, AST, TNF-α, IL-8, fatty acid, MDA and SOD, and increased ISI ( P 〈 0.01 or P 〈 0.05). Compared to the control group, most of the parameters were better in the raisin tree seed group except MDA and SOD ( P 〈 0. 05). Conclusion: The exract of raisin tree seed has a better therapeutic efficacy on high fat diet-induced NASH compared to Tioprunin combined with Essentiale Forte. The underlying mechanism of this effect may be related to increasing insulin sensitivity, antioxidation, and inhibiting inflammatory cytokines.
出处 《浙江中西医结合杂志》 2009年第1期12-14,共3页 Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
基金 浙江省中医药科技计划项目(No.2007C4111)
关键词 非酒精性脂肪性肝炎 大鼠 枳椇子 non-alcoholic steatosis hepatitis rat raisin tree seed
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