对泌尿生殖道支原体感染治疗失败患者再治疗体会

Re-treatment of urogenital infection with Mycoplasma

目的:探讨泌尿生殖道支原体感染及治疗支原体感染失败的原因,并总结治疗经验。方法:对治疗失败的支原体感染患者进行回顾性分析,调查治疗失败的原因,同时对泌尿生殖道分泌物进行培养和药敏试验,并再次进行治疗。结果:治疗失败的68例患者中,解脲脲原体感染37例,占54.41%,居首位;在性别分布上以女性为多。药敏试验表明:对交沙霉素、米诺环素、多西环素较敏感;对红霉素、阿齐霉素、氧氟沙星和环丙沙星相对耐药。患者的性别、疗程、菌量及用药情况等对疗效均有影响。对患者进行个体化再治疗后,治愈率为91.18%,疗效满意。结论:对泌尿生殖道支原体感染的患者应根据药敏结果选择抗生素,这是临床上治疗支原体感染的首要原则,但是还应行个体化的治疗。

Objective： To improve the treatment of Mycoplasma infection in urogenital tracts. Methods： Sixty-eight patients with Mycoplasma infection in urogenital tracts and the failure of treatment were studied, including 27 males and 41 females, at the age of 18-52 years. The reasons of therapeutic failure were analyzed, followed by the Mycoplasma cultivations and the antibiotic-sensitivity testing. The patients were treated again. Results： Among 68 patients, most were infected with Mycoplasma urealytium （37/68, 54.41%）; followed by mixed infection with M. urealytium and M. hominis （21/68, 30.88%）, and then pore infection with M. hominis （10/68, 14.71%）. The female patients were more than the males. Antibiotic-sensitivity tests showed that the strains of Mycoplasma were sensitive to josamyein, minocycline and doxycycline, whereas resistant to erythromycin, azithromycin, ofloxaein and eiprofloxacin. The individualized treatment was prescribed in all 68 patients and the cure rate was 91.18%. Conclusion： Individualized treatment according to the results of antibiotic-sensitivity testing is necessary in treating the Mycoplasma infection of urogenital tract.