过期妊娠孕妇机体过氧化与胎盘功能关系的研究

Study on the relationship between peroxidation and placental function in prolonged pregnancy.

测定足月妊娠及过期妊娠红细胞超氧化物歧化酶（ＳＯＤ）和全血谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活力、血清脂质过氧化物（ＬＰＯ）及血清Ｅ３、ｈＰＬ及血浆ＴＸＢ２和６－ｋｅｔｏ－ＰＧＦ１α（６ＫＰ）水平。结果显示过期妊娠者ＳＯＤ、ＧＳＨ－Ｐｘ活力明显低于正常足月妊娠，Ｐ＜０．００１；ＬＰＯ明显高于正常足月妊娠，Ｐ＜００５；同时Ｅ３、ｈＰＬ下降，Ｐ＜０．００１；６ＫＰ亦降低，Ｐ＜０．０５。在过期妊娠组中，胎心监护ＮＳＴ低评分、存在胎儿缺氧者为２１４３％，显著高于对照组（９．０９％），Ｐ＜０．０１。研究表明过期妊娠的发生与体内过氧化有关，其胎盘老化、功能减退的病理生理变化以及胎心监护低评分与氧自由基过多及其清除物减少明显相关。

Objective:To study the pathophysiological changes of prolonged pregnancy and the relationship between oxidation and placental functhion.Methods:Maternal red blood cell superoxide dismutases(SOD)、gluthathione peroxidase(GSH-Px)、serum lipid peroxide(LPO),as well as maternal serum E3、hPL and plasma TXB2、6-keto-PGF1α(6KP)were measured in normal term pregnancy and prolonged pregnancy.Results:In prolonged pregnancy,SOD、GSH-Px activity decreased significantly(P<0001);and LPO level increased significantly(P<005).Meanwhile,maternal serum E3、hPL level were significantly lower than that in control group(P<0001),6KP level reduced obviously(P<005).In Prolonged pregnant women,fetal Fischer's score of NST test≤7' accounted for 21.43%,which was markedly higher than that in control group (909%),P<0.01.Conclusion:The prolonged pregnancy was associated with over oxidate.The pathophysiologic change of placenta,fetal heart monitor low score were associatal with oxygen free radical increasing and its scavenger reducing. \ \