ECHO方案为基础的化疗治疗小细胞肺癌疗效观察

Observation of combination chemotherapy based on ECHO regimen in small cell lung cancer

目的比较研究ＥＣＨＯ和ＥＣＨＯ加ＥＰ方案治疗小细胞肺癌的疗效、生存时间及毒副反应。方法５３例小细胞肺癌接受系统化疗，２６例在ＥＣＨＯ组，２７例在ＥＣＨＯ加ＥＰ组。结果近期有效率比较，ＥＣＨＯ组局限期８５．７％（６／７），广泛期７８．９％（１５／１９）；ＥＣＨＯ加ＥＰ组局限期８３．３％（５／６），广泛期７１．４％（１５／２１）。中位生存期两组分别为１２月和１１月。以上结果统计学处理均无显著性差异（Ｐ＞０．０５）。毒副反应主要为轻中度的消化道反应、骨髓抑制，ＥＣＨＯ加ＥＰ组消化道反应发生率较ＥＣＨＯ组高（Ｐ＜０．０１）。结论结果表明两组方案可作为小细胞肺癌的首选诱导缓解方案，ＥＣＨＯ加ＥＰ方案有助于克服ＥＣＨＯ使用中的耐药情况。

Objective To observe comparativelly the response rate 、 the survival time and the toxicity of either ECHO or ECHO+ EP combination chemotherapy in small cell lung cancer.Methods The 53 cases of small cell lung cancer were treated with systematic combination chemotherapy,26 cases in ECHO subset and 27 cases in ECHO+ EP subset.Results The response rate was 85.7%(6/7) and 83.3%(5/6) in limited stage,78.9%(15/19)and 71.4%(15/21)in extensive stage, respectivelly. The difference in median survival was 12 months and 11 months. The results showed the response rate and median survival in tow subsets were not statistically significant (P>0.05).Toxicities covered mainly the modest degrees of digestive disorder and myelosuppression 〔ECHO+ EP had higher toxic effect in digestive disorder(P<0.01)〕.Conclusion ECHO and ECHO+EP can be used as the primary regimens of renmission induction in the treatment of small cell lung cancer. ECHO+EP regimen is benificial to overcome the drug resistance of ECHO regimen