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放射性核素示踪技术检测端粒酶活性的研究进展

Development on detecting human telomerase activity with radionuclide tracing technology
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摘要 人端粒酶(telomerase)与人类的衰老与肿瘤发生密切联系;其主要组成成分之一——人端粒酶催化亚单位(hTERT)是端粒酶的限速亚单位,具有重要的临床应用价值与研究意义。检测端粒酶活性,尤其是hTERT活性,不仅有助于临床诊断肿瘤,而且对于进一步开展端粒酶研究具有重要作用。本文综述放射性核素示踪技术检测端粒酶活性的研究进展。 Human telomerase, especially human telomerase reverse transcriptase （hTERT）, plays an important role in hu man aging and tumorigenesis, hTERT represents the major determinant of telomerase activity. Since its potential clinical sig nifieance, the measurement of hTERT expression conduces to not only tumor diagnosis, but also the research of telomerase The development of detecting human telomerase activity with radionuelide tracing technology was reviewed in this article.
作者 刘萌 王荣福
机构地区 北京大学第一医院核医学科
出处 《中国医学影像技术》 CSCD 北大核心 2009年第1期18-20,共3页 Chinese Journal of Medical Imaging Technology
基金 国家重点基础研究发展计划基金-973计划基金(2006CB705705) 国家自然科学基金(30470498 30670583) 北京大学985II期基金(985-2-056) 放射性药物教育部重点实验室开放基金(0706)
关键词 人端粒酶催化亚单位 端粒酶 放射性核素示踪技术 Human telomerase reverse transcriptase Telomerase Radionuclide tracing technology
分类号 R817.4 [医药卫生—影像医学与核医学]
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参考文献21

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二级参考文献10

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中国医学影像技术
2009年 第1期

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