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Megalin mRNA在胆石症病人胆囊上皮细胞的表达变化及其意义

Expression of Megalin mRNA expression in gallbladder epithelium of patients with cholelithiasis and its significance
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摘要 目的探讨和分析MegalinmRNA在胆石症病人胆囊上皮细胞的表达变化及其意义。方法检测62例胆结石和38例胆囊息肉病人胆囊内皮细胞的MegalinmRNA表达水平,应用RT-PCR分析Megalin的表达。结果发现胆结石病人胆囊上皮细胞表达MegalinmRNA水平远低于胆囊息肉病人的水平,同时拎测两纽痫人血清胆固醇水平的结果显示血清胆尉醇无差别。结论胆囊上皮吸收胆固醇机制可能在胆结石的病理发生过程中有再要的意义。 Objective To detect and analyze the change of Meaglin mRNA expression in gall- bladder epithelium of the cholelithiasis and gallbladder polyp patients. Methods The expression level of Megalin mRNA was determined in 62 ceses of cholelithiasis and 38 cases of gallbladder polyp by RT-PCR. Results Megalin mRNA was expressed in the gallbladder epithelium and the expression was significantly different between the 2 groups. Conclusion The mechanism of cholesterol absorp- tion in gallbladder epithelium might play an important role in gallstone pathogenesis.
出处 《中华肝胆外科杂志》 CAS CSCD 北大核心 2009年第1期20-21,共2页 Chinese Journal of Hepatobiliary Surgery
关键词 胆囊切除术 Megalin分子 胆囊上皮细胞 Cholecystitis Megalin mRNA Gallbladder epithelium
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