盐酸布比卡因与不同药物配比用于腰-硬联合麻醉行剖宫产的评价

Comparison of the effects of bupivacaine combining different drugs in combined spinal-epidural anesthesia with cesarean section

目的探讨盐酸布比卡因与不同药物配比用于腰-硬联合麻醉行剖宫产的效果评价。方法90例剖宫产术患者随机分为A、B、C3组,每组30例,A组0.75%盐酸布比卡因1.0ml+麻黄素1.0ml(30mg);B组0.75%盐酸布比卡因1.0ml+麻黄素1.0ml(30mg)+10%GS1.0ml(共实用2.0ml);C组0.75%盐酸布比卡因1.5ml+10%GS1.0ml(共实用2.0ml),观察15min最高麻醉平面、止痛效果、低血压及恶心呕吐、头晕、胸闷、心悸等不良反应发生率。结果B组与A组比较差异无统计学意义,C组与A组比较差异有统计学意义(P<0.05)。结论CSEA用于剖宫产手术,0.75%盐酸布比卡因1.5ml+10%GS1.0ml(实用2.0ml)可安全有效的运用。

Objective To estimate the clinical effects of bupivacaine combining different drugs in combined spinal-epidural anesthesia（CSEA） with cesarean section. Methods 90 patients undergoing cesarean section were divided into three groups randomly for receiving CSEA with 0.75 % bupivacaine 1 ml and ephedrine 30mg in group A （ n = 30 ）, 0.75 % bupivacaine 1 ml, ephedrine 30mg and 10% GS 1ml in group B（ Practical volume 2ml, n = 30） ,0.75% bupivacaine 1.5ml and 10% GS lml in group C（ Practical volume 2ml, n = 30 ）. The highest plane of block analgesia, analgesic effect, hypotension, nausea and vomiting, dizziness, chest tightness and palpitation were assessed after 15 min of CSEA. Results There＇s significance difference between C with A group（ P 〈 0.05 ）, and no difference between B with A group（ P 〉 0.05）. Conclusion It＇s a good anesthesia method for cesarean section with CSEA, and 0.75 % bupivacaine 1.5 ml with 10 % GS 1 ml （ Practical volume 2ml ） can obtained a better anesthesia effect.