高甘油三酯血症患者动脉僵硬度与超敏C反应蛋白的相关性研究

The relationship between arterial stiffness and serum levels of high-sensitivity C-reactive protein in patients with hypertriglyceridemia

目的探讨高甘油三酯血症患者动脉僵硬度与超敏C反应蛋白(hsCRP)的关系。方法以脉搏波速度(PWV)水平作为动脉僵硬度的评价手段。112名高甘油三酯血症患者根据动脉硬化的程度分为低PWV组和高PWV组,分别测定肱踝脉搏波传导速度(ba-PWV)和hsCRP,并收集相关临床资料。结果高PWV组log hsCRP水平显著高于低PWV组(P<0.05)。偏相关分析显示在校正年龄、性别、吸烟史、合并用药情况、冠心病、高血压、血脂谱、空腹血糖、胰岛素抵抗指数后ba-PWV和log hsCRP正相关(r=0.261,P=0.039)。多元回归分析显示年龄(P<0.01)、收缩压(P<0.05)及log hsCRP(P<0.05)与ba-PWV相关。结论高甘油三酯血症患者中hsCRP与ba-PWV水平相关,提示动脉僵硬度可能与全身的炎症状态相关。

Objective To investigate the relationship between pulse wave velocity （PWV） and high-sensitivity C-reactive protein （hsCRP） in patients with hypertriglyceridemia. Methods 112 patients with hypertriglyceridemia were divided into low PWV group （n =56） and high PWV group （n =56）, brachial to ankle PWV （ba-PWV） and serum levels of hsCRP were measured respectively. The related clinical data were collected in all patients. Results The serum levels of log hsCRP were higher significantly in high PWV group compared with low PWV group （ P 〈 0.05 ）. Mter adjusting for age, sex, smoking, drugs, coronary heart disease, hypertension, lipid profile, fasting blood glucose （FBG） and insulin resistance index （ HOMA-IR）, ba-PWV was positively correlated with log hsCRP （ r = 0.261, P = 0. 039 ）. Multiple stepwise regression showed that age （ P 〈 0. 01 ）, systolic blood pressure （ P 〈 0. 05 ） and log hsCRP （ P 〈 0.05 ） were correlated with ba-PWV. Conclusion Age, systolic blood pressure and hsCRP are independent predictors to ba-PWV in patients with hypertriglyceridemia. Arterial stiffness is correlated with the systemic inflammatory state.