2型糖尿病患者血清瘦素与颈动脉内膜中层厚度的相关性研究

Association of serum leptin with intima-media thickness of carotid artery in type 2 diabetes patients

目的探讨2型糖尿病（T2DM）患者血清瘦素水平与颈动脉内膜中层厚度（IMT）的关系。方法选择35例2型糖尿病患者、16例正常对照者，分别测定其血清瘦素、空腹血糖、糖化血红蛋白Alc（HbAlc）、C肽、血脂、血压、体重指数（BMI）及腰围，同时使用高分辨率超声检测双侧颈动脉IMT。结果T2DM患者血清瘦素浓度与颈动脉IMT呈显著正相关。结论血清瘦素浓度与颈动脉IMT的增厚有关，提示瘦素可能是导致T2DM患者动脉粥样硬化中的一项危险因素。

Objective To investigate the relationship between serum leptin and carotid intima-media thickness in patients with type 2 diabetes mellitus. Methods 35 patients with type 2 diabetes mellitus （DM） and 16 normal controls were studied. Fasting serum leptin, fasting glucose（ FBG）, HbAlc, C-peptide, lipids, systolic（ SBP）, diastolic blood pressure（ DBP）, body mass index （BMI） and waist circumference （WC） were measured in all subjects. The intima-media thickness （IMT） of common carotid artery was measured by high-resolution ultrasound imaging. Results IMT of T2DM was positively correlated with leptin concentration. Conclusion Serum leptin concentration is independently associated with the IMT of carotid artery, which suggest that leptin may be an independent risk factor of atherosclerosis.