急性脑梗死患者血清氧化型低密度脂蛋白水平变化及其与TOAST分型的关系

Changes of Serum Oxidized Low-Density Lipoprotein Levels in Patients with Acute Cerebral Infarction and Their Relationship with TOAST Subtypes

目的:探讨脑梗死患者血清氧化型低密度脂蛋白(oxLDL)水平变化及其与脑梗死的TOAST病因学分型之间的关系。方法:应用酶联免疫吸附法(ELISA)检测70例急性脑梗死患者血清oxLDL水平,按TOAST分型进行分组,对各亚组与52例健康对照组进行比较。结果:所有急性脑梗死患者、大动脉粥样硬化性卒中组及小动脉闭塞性卒中组血清oxLDL均较对照组显著增高(P均<0.01);大动脉粥样硬化性卒中组血清oxLDL水平显著高于其他亚组(P均<0.01)。结论:血清oxLDL在脑梗死急性期升高,并与TOAST分型中的大动脉粥样硬化性卒中等类型关系紧密,可作为脑梗死急性期的血清标志物之一,提示斑块不稳定。

Objective： To investigate the changes of serum oxidized low-density lipoprotein （oxLDL） levels in patients with cerebral infarction and their relationship with the Trial of Org 10172 in Acute Stroke Treatment （TOAST） subtypes of cerebral infarction. Methods： The levels of oxLDL in 70 patients with acute cerebral infarction were measured by enzyme-linked immuno-sorbent assay （ELISA）. The patients were divided according to TOAST subtypes, and all the subgroups compared with the 52 healthy controls. Results： Serum oxLDL levels in all the patients with acute cerebral infarction in a large artery atherosclerotic stroke group and a small artery occlusion group were significantly higher than those in the control group （all P 〈0.01）. Serum oxLDL levels in the large artery atherosclerotic stroke group was significantly higher than those in other subgroups （all P 〈 0.01 ）. Conclusion. Tne levels of serum oxLDL were increased during acute cerebral infarction, and it had close relationship with the types of large artery atherosclerotic stroke in TOAST subtypes. So it might be used as one of the serum markers during acute cerebral infarction, and indicating the instability of plaque.