摘要
目的探讨Waldenstrom巨球蛋白血症(WM)的临床特点,提高对这种疾病的认识及诊治水平。方法对本院1995年11月至2007年10月确诊为WM的15例患者进行回顾性分析。结果患者的中位发病年龄68.5(60~79)岁,男/女=2.75/1。患者的主要表现为乏力、消瘦、脾大、淋巴结肿大。15例患者分别接受烷化剂、核苷类似物、沙立度胺、硼替佐米等治疗。15例患者的随访时间为4个月~10年,中位随访时间82个月。结论WM多发于老年人,男性多见,临床表现多样,化疗是主要的治疗手段,但不能治愈,新药硼替佐米,沙立度胺有望提高WM的疗效。
Objective To explore the clinical characteristics of Waldenstrom macroglobulinemia (WM) and enhance the level of diagnosis and treatment. Method The data of 15 patients with WM in our hospital from November 1995 to October 2007 were retrospectively analyzed. Results The median age was 68. 5 ( 60-79 ) years, male/female = 2. 75/1. Main clinical manifestations were fatigue, loss of weight, splenomegaly and lymphadenopathy. All the patients accepted the treatment of alkylating agents, purine nueleoside analogs, bortezomib or thalidomide respectively. The follow-up period for the patients was 4 months to 10 years and the median follow-up time was 82 months. Conclusion WM may often be seen in old male patients with varied clinical manifestations. The primary treatment is chemotherapy, but the disease is incurable. Bortezomib and thalidomide may improve the therapeutic effect.
出处
《中华内科杂志》
CAS
CSCD
北大核心
2009年第3期193-195,共3页
Chinese Journal of Internal Medicine