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桂枝汤有效部位A对体温双向调节作用及其机理研究*——对下丘脑NE、DA、5-HT含量的影响 被引量:26

DualDirectional Thermoregulation and Its Mechanism of Active Fraction A of Guizhi decoction ——Effect on NE,DA and 5HT in Hypothalamus of Rats
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摘要 在酵母诱导的发热大鼠中,桂枝汤有效部位A(Fr.A)能降低下丘脑5-HT、NE、DA含量;在安痛定诱导的低体温大鼠中,能升高5-HT含量。结果提示,Fr.A为桂枝汤体温双向调节作用的一种物质基础,影响中枢神经递质5-HT的水平是其机理之一; Active fraction A (Fr.A),isolated from Guizhi decoction, could lower body temperature along with a decrease of 5hydroxy tryptamine (5HT)content in hypothalamus in febrile rats induced by zymosa. On the other hand,it made fallen temperature rise and increased the 5HT level in hypothalamus in hypothemic rats induced by aminopyrine. The results showed that Fr.A regulate temperature in a dualdirection pattern and the mechanism was partially related with its influence on content of 5HT in hypothalamus; and its antipyretic effect was associated with its reducing the contents of NE and DA in hypothalamus.
出处 《中国实验方剂学杂志》 CAS 1998年第3期14-16,共3页 Chinese Journal of Experimental Traditional Medical Formulae
基金 国家自然科学基金
关键词 桂枝汤 有效部位A 体温双向调节 NE 多巴胺 5-HT Active fraction A of Guizhi decoction Duladirectional thermoregulation norepinephrine dopamine 5hydroxytryptamine
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