不同剂量曲马多用于下颌骨骨折内固定术后静脉镇痛效果比较

Comparison of effect of different dosages of tramadol in intravenous analgesia after mandible fracture operation

目的:观察不同剂量曲马多用于下颌骨折术后镇痛的效果及不良反应。方法:选择下颌骨骨折病人60例(ASAⅠ级)随机分为两组,Ⅰ组(n=30),曲马多10mg/kg+氟哌利多5mg+0.9%生理盐水稀释至100ml注入镇痛泵;Ⅱ组(n=30),曲马多15mg/kg+氟哌利多5mg+0.9%生理盐水稀释至100ml注入镇痛泵,分别于拔除气管插管后为病人施行静脉自控镇痛。记录术后48h内病人镇痛效果及不良反应。结果:两组镇痛效果差异无显著性(P>0.05),但Ⅱ组不良反应发生率明显高于Ⅰ组(P<0.05)。结论:曲马多10mg/kg用于术后静脉镇痛效果满意,不良反应发生率低。

Objective ：To observe the analgetic effect and side effect of different dosage of tramadol in patient controlled intravenous analgesia（PCIA） after mandible fracture operation. Methods：Sixty patients undergoing mandible fracture operation were randomly divided into two groups with thirty cases each.In group Ⅰ,tramadol 10mg/kg with droperidol 5 mg was diluted to 100 ml for PCIA;in group Ⅱ tramadol 15 mg/kg with droperidol 5 mg was diluted to 100 ml for PCIA. The analgetic effect and side effect were collected at 4,8,12,24,48 h after operation. Results ：There was no significant difference in analgetic effect between two groups（P〉0.05）, but the rate of side effect of group Ⅱ was significant higher than that of group Ⅰ （P〈0.05）.Conclusion：Tramadol 10 mg/kg for PCIA is effective and safe.